Dr Perricone

Health and Life Hacks from the Legendary - Dr Perricone

Dr Perricone with Ross Franklin on the PG Podcast

Why you should listen - 

Dr. Perricone is the modern age Nikola Tesla. He has development over 160 patents across a wide array of industries and has written over 5 bestselling books. In this episode of the PG Podcast, Founder and CEO Ross Franklin asks questions that go beyond the surface to undercover the life hacks and biohacks that Dr. Perricone uses to take his performance to the next level.


Podcast with Dr. Perricone

Ross Franklin: On the podcast today we have a legend. He is the author of five New York Times bestsellers; he's a scientist with over 160 patterns, he is a world-renowned educator and regarded as the father of the inflammation theory of aging. He is Dr. Perricone Perricone.

Ross: Thank you so much for joining us.

Dr. Perricone: Ross thank you and thank you for that very generous introduction.

Ross: It’s such an honor to have you on the show we have so much to talk about so where do we get started here? I think we should start with can you tell us a little about how did you get started?

Dr. Perricone: You know it's unusual a story because I was actually an English literature major at undergrad and at that time I finished up my degree and I had to go in the army for a while. And when I came out of the army, I actually worked for a nonprofit organization called the Muscular Dystrophy Association and I really enjoyed it because it was patient services but there was also fundraising administration and a lot of television because it was associated with the journalist television. So I learned all about that but working with the patients there, you only live in the hospital. So I came to the conclusion I really wanted to go into medicine, problem was I was an English literature major and had no science background. So I talked with people, and they say if you go ahead and take core requirements at night and so I did that and started meds school at 31 which is kind of unusual, and I got there, and so I was probably one of the few people that hadn't taken premed I was not a science major. But I could read, and I really enjoyed the work, and I was also at Michigan State University where they had two different programs. One was called track one which was traditionally you went to classes, lectures and then you took a test, then you did your clinical work after that. The other one was called track two and was problem-based, so you would have to basically get a problem like say back pain or chest pain you would learn all of the physiology, anatomy, pharmacology, psychology of chest pain or back pain. And this is what you will learn to assign a large amount of reading, and you're on your own, and of course, you had to attend anatomy classes and things like that. So I took that and found that by pure accident that for some reason if I hear something like a lecture it really sticks with me and so I did all my notes into a tape recorder and started listening and realized that I could accelerate my course. So I went to the dean said and can I move forward more quickly? And they said yes. So at the end of the day, I did that loved it and actually graduated in medical school in two and a half years, so it saved me a lot of time. I then went on to do pediatrics at the Yale program a four-year and then went on to do dermatology because a close friend of mine was a pediatric dermatologist. But while I was doing all these things in meds school I came across some really interesting things. One was I was looking under the microscope at squamous cell cancer, and I noticed there was inflammation surrounding it and then looking at them under the microscope with other disease processes this is called histopathology I realize that every disease process had some form inflammation that was visible under the microscope. So I ask my professors that is it possible that inflammation may be mediating for driving some of these diseases and the answer was kind of a flat no. You know, don't bother with this stuff but I was very interested, and I was also a nutritionist. So I found that okay well this isn't an inflammatory process and I know that all antioxidants act as an anti-inflammatory. Because when I was at Yale we found it in two children who had asthma and we gave them a large amount of vitamin c we cut down the amount of asthma attack by 50% because it was lowering the inflammatory cascade. So I took some vitamin c and applied it to my skin one day after a bad sunburn and on half of my face anyway and I found out that it actually resolved it. So I start putting this together that okay inflammation is definitely behind diseases, and I thought wrinkling and disease of aging, very controversial. So I started working and doing my research, and I said okay what was causing the internal inflammation? Well, being a nutritionist I said what we do four times a day? We eat! So I started looking at the relationship between food and systemic inflammation, and sure enough, it was probably pretty simple you know what grandmother told us to eat fresh fruits,  vegetables and fish. When I put patients on that diet, the measured systemic inflammation rapidly came down, so I had this whole concept. So when I started my practice in dermatology after completing that, I found out that I can put patients on an anti-inflammatory guide and all, so antioxidants and also give them traditional Western medicine but adding the nutrition side, they also improve very, very rapidly. Everything then was amazing, you know when I was doing my dermatology residency looking under the microscope young skin has no inflammation but older skin even if there's no pathology there, there's no a lesion had inflammation. I said okay so it's the way that I’ll approach this is beauty from the inside out equality shows the inequality anti-inflammatory diet but then from the outside in is taking antioxidants and other anti-inflammatory and put it in a base that would actually penetrate the skin. So I started getting my first patents while I was still a resident and then moving forward and follow this right through my practice but now doing larger clinical studies and so patents started coming in. I actually had no intention of ever starting a company I just wanted to take my technology and go to the big players out there, the Johnson and Johnson, Loreal and Estee Lauder and show them my clinical studies that if they can just add these antioxidants to their creams with the right penetrator and get really good clinical results.

Ross: I was going to ask you so 160 patents? So you must have got started early, so that makes sense.

Dr. Perricone: That's how I started early and hear this I presented this all over the world and nobody was interested. Finally one company I won’t mention the name called me over and said let me tell you the way this works. We put oil, water, and perfume in a jar and we make a ton of money.

Ross: It’s all filter

Dr. Nicolas: There is no downside because there’s nothing there that could hurt you. So don't call us we'll call you. Sounds a little discouraged because I have no savings everything I had I put into my intellectual property and I said I am going to start my own company. Everybody just shook their head you can't-do that, you can't possibly compete against the big guys. And I said yes I would because it is going to be science-based. And so I started, and a lot of things happen, I wrote my first book which became another one of New York Times bestsellers. Sold couple million copies, was given a public television special to talk about diet and beauty from the inside out and the outside in, and business took off. It just kept on growing so now it's an international skin care business, and I had no idea of that whatever happened. That was not my plan but am very happy with it because I've changed the whole industry now.

Ross: What were some of the first product when you first launched and how much has it transformed?


Dr. Perricone: Because you know real basic vitamin c I know is important but regular vitamin c or ascorbic acid actually it irritates the skin. Because it is acidic, it penetrates the skin and interacts with the free iron in your skin. By the way, the older you are, the more free iron you have, and it causes this chemical reaction called a Fenton reaction which produces a very bad free radical hydroxyl radical. So I said okay that’s not good. So I came across this other vitamin C its called ascorbyl palmitate, so its vitamin c with palmitic acid attached and it completely gets in the skin like 10 to 15 times faster, does not cause a Fenton reaction and rapidly increase collagen plus drops inflammation. So vitamin c ether we call it or ascorbyl palmitate it was number one. Lipoic acid super-duper antioxidant, it’s called universal because it’s both fat and water soluble. Super powerful it turns off a lot of transcription factors which we'll talk about more because they are important. So vitamin C was the number one Alpha Lipoic acid was number two and then the ultimate discovery was DMAE, and this long name is called Dimethyl Amino Ethanol. And the reason I chose it was at one time it was a prescription product for the brain for attention deficit disorder, but then the FDA drop it because there was not enough study but it was harmless. So I went to the help food stores to find a capsule for increase cognitive function, but I knew that it also acts as a solvent, so I was looking for penetration and answers. So I took the DMAE and put it into cream and was applying to a patients face and I got called on the phone, I came back, and the face was lifted. So it was working on something called acidochronic and so here is this wonderful antioxidant, anti-inflammatory. So vitamin c, lipoic acid, and DMAE were the three I started with, and they are absolutely still the core of the program because they are working steadily, they are really effective, they change the way you look, and they are based on science.

Ross: Yeah.

Dr. Perricone: So I moved over from there because the other thing I do at the meds school was when I was doing my psychiatric rotation when we gave people medications that were psychoactive their skin would change. And the at the same time I was taking histopathology and then I found out that first of all, we learn in embryology that the skin and the brain come from the same level of tissue called the epiderm. So if they are derived from the same thing under the microscope skin and brain look fairly much alike. Brain changes with medications, I called it the brain-beauty connection so when I came across DMAE, I said this is perhaps it. So from that brain-beauty connection, there's DMAE then my neuropeptide line which is hugely effective and still is probably the biggest seller in the world and other active ingredients that affect the brain and one of them, of course, is hydrogen water. Because once again it affects the brain profoundly but also affects the skin.

Ross: And you have a hydrogen line of cosmetics as well right? Isn’t that the hydro line?

Dr. Perricone: Yes when I started looking at it, I discovered the world literature constantly, I was looking for the magic bullet. What is the magic anti-inflammatory? And I found out that hydrogen which is the smallest and the first element formed in the uterus and its universe. So, I think 90% of the universe is still made up of just hydrogen it actually has anti-inflammatory activities. So it really caught my eye over seven or eight years ago, I followed the literature very closely and saw amazing things. Mostly you know animal studies, a couple of good studies, human studies you know very good journals. So I start looking at myself I said this is really anti-inflammatory what else can it do? And the more I studied it, the more impressed I was because this little molecule which is the actual basis of the universe can affect this in a very positive ways. So it came from Japan, and I found out Japan was using hydrogen as a therapeutic in hospitals, but also they made hydrogen water. They would dissolve hydrogen in water just like we dissolve sugar and say tea. And that hydrogen water had all of these therapeutic benefits and but once again I was skeptic. And so I went over to Japan and talked with them watched the process of how they made the hydrogen water. Got some literature I had to try one of those studies myself. Because my experience has been unfortunately when I tried to reproduce scientific studies in the past 50% of the time it did not work. So I started to do my own study with hydrogen, and my study was I wanted to do something basic because hydrogen gives you energy when you drink hydrogen water. I said okay, is it real? And is there a way to prove that? So I took on 20 subjects, and I know as dermatologist you must know biochemistry that there's a molecule in the skin an enzyme called NADH. And NADH and this little team call NADH oxidized reduced form actually is one the key energy producers in our bodies that is really responsible for producing ATP. So I knew that for us so that means we can measure it by putting a light on it, it’s the only thing in the skin for us as well. So we measured that we quantified it then we gave these subjects some 500 mL of hydrogen water just had them drink it right down. So we started measuring changes of NADH in real-time it started upregulating in two minutes. So imagine how small hydrogen is you can drink it, it goes into your stomach, and then two minutes it's on your skin. We watched the NADH come up and at 15 minutes maxed up 18 out of 20 to 121/2% increase. Now an enzyme is in the mitochondria and makes energy go up 121/2%, I mean that was like shocking. Okay so that answer the question is a real, it's real. And why is the energy so important? Of course, we need energy to do everything but what’s really interesting is young cells are characterized by high energy and as we get older that energy drops. So that means if the cell cant repair itself as well it can’t take in nutrients as well, it can’t kick out waste as well. And work out of Harvard showed that molecule NAD half of this process when it goes up it can actually make the mitochondria talk to the nucleus of the cell and mitochondrial gets younger. So energy is the is the key to youth, energy is a key to health if you are sick your energy goes down. So here I have this wonderful little molecule, non-toxic on the deep diving bells 1940s at 20 atmospheres that’s 20 times more pressure than we have sitting here giving this interview and they put it 49% in the tanks because then they have replaced oxygen because oxygen is toxic under the 20 atmospheres no toxicity. So we'll look at our hydrogen water on like several orders of magnitude lower than it is. No toxicity to hydrogen, it is odorless, it is tasteless we can put up water it doesn't affect the taste, it is extremely safe and very effective. So what did I find? Powerful anti-inflammatory traps inflammation rapidly in the body. You know you are going to know immediately after drinking it, and within 10 or 15 minutes you'll feel the energy, but this is strange. I have never felt nor if you ever felt energy that wasn't derived some food source before or from a stimulus.

Ross: Right.

Dr. Perricone: So it wasn't a carbohydrate it wasn't a protein, it wasn't fat, and there's no caffeine or other stimulants. So what does that feel like? What happens is the first new users develop credible mental clarity. I mean like saying yeah I felt great when I came in, but I feel even better now.

Ross: Yeah am having 3 and 4 Days things, and its energies are through the roof, and you are saying, so what's going on in the body exactly? So you're saying that the hydrogen in the water is increasing the body's NAD, NADH+ and that’s energizing the cells?

Dr. Perricone: What’s happening is than that. Hydrogen affects some messengers in the cell, and the messengers are called transcription factors by the biochemist, so we're just going with messengers transcription factor may confuse people. So there are two major ones that I want to talk about, and I started talking about this 20 years ago in a book. Number one there's a bad transcription factor I call the bad messenger, and it is called NF-kappaB, and it is part of our immune system, and it helps regulates information. So if we ever have something like parasites or something NF-kappaB up-regulates you know all these information helps with getting rid of the data. The problem is NF-kappaB just keeps on going up as we age so NF-kappaB is the bad guy. So I was looking for how can I turn off NF-kappaB? Paul Carson did a beautiful job, but hydrogen does a better job so hydrogen can stop this. So here is what happens the messenger goes from inside the outer portion of the cell called the cytosol, and it looks at free radicals and says hey there's a problem here. So it then moves to the nucleus and then attaches to the DNA and starts making gene expression of hundred Pro inflammatory proteins called cytokines and they flood the body. Inflammation is the final common pathway to disease nature, and we have to turn it off. And in the brain, brain fog eventually Alzheimer's or Parkinson's or dementia or bad memory it’s a bad actor and offs NF-kappaB. So it actually turns off NF-kappaB.

Ross: So this brings us to the epigenetic component of this right it’s pretty an off and on the genes.

Dr. Perricone: Right so it on work things call relaxins, and it turns off about 650 bad genes and up-regulates about 500 good genes, good old tiny little bad ones hard to believe. And then when you look at it too you say okay so on the other side there’s another transcription guy but it’s a good guy and that's call Nrf2. So the reason I came across Nrf2 is being a nutritionist and working for years with phytochemicals you know things like broccoli and cauliflower and all of the things that are true green by the way. It has an incredible, positive effects but the levels were not high enough in the serum to account for it, so it was this mystery we had. Then we found out that these vital nutrients were even things like some of the spices like cinnamon actually has a molecule that tricks the cell and makes it look like as under oxidative stress, makes it look like its free radical but its very mild. And when that happens it turns on the good transcription factor called Nrf2. Nrf2 then does what NF-kappaB does; it leaves the outer portion of the cell goes into the nucleus and attaches to the DNA and something called ARE spot. It’s an anti antioxidant response element, and now the genes start making over a 100 anti-inflammatory antioxidants, proteins, and enzymes called phase 2 proteins. That explains how these nutrients work fights our defense. So now instead of having to take in antioxidants which are canceled out by free radicals, we turn ourselves into factories that are making antioxidants using Nrf2. And of course it was hydrogen that operates Nrf2, and I don't know why because it does not look like radical.

Ross: So just hydrogen is doing all of this in the body it is amazing.

Dr. Perricone: So if we start looking at just organ system. Okay so I’m most excited about the brain, the fog makes you feel centered, you feel grounded, and that means focus, and when it comes down to it, you know this, and I think every successful person knows this, the better you're focused, the more successful you are. You focus on that goal everyday whatever you want to be, if you want to be healthier, you want to get an education, you want to earn a living, you want to have a great relationship so focus. So I discovered about 40 years ago being coerced by my brother that meditation was an amazing thing and I was busy and I thought should I exercise and also have time for meditation. But I started doing it because it was good. A study out of Harvard one day did these MRIs and brains so they actually had increased density of neurons and I said I could always use a few more neurons as I was getting older. So I started doing that and found out that actually when I drank my hydro water before my meditation ii’s a much more focused, it's a deeper medication. So I’m almost at the point now I know this sounds crazy I’m thinking of hydrogen as a Spirit molecule because it actually enhances spirituality because it enhances your meditation. So this wonderful thing, the first thing they created in the universe was hydrogen, it is the most abundant, its the tiniest and has all of these incredible positive benefits for you. So I did that, and then I came back I started thinking about making a big investment to make hydrogen water. I want to make it available to everybody not just here but throughout the world, and I believe it can happen. It has a profound request on healthcare costs, but also I want to get this water to third world countries because they have a number of problems bad water, parasites and other infections. This can help a lot of people, so that's going to be our big goal, but I also own a skincare company. And I said well what if I invent a way of putting hydrogen into cream. Hydrogen, of course, it is very light, it dissipates, but there's this whole other thing I worked on. I own a pharmaceutical company, and at that time I was very interested in a molecule called nitric oxide. Nitric oxide was like the molecule of the year 1997 there were two double prizes given. Nitric oxide is something called the Castle transmitters, a gas and it does things like relaxing the arteries can help with wound healing can help with memory formation, and so all pharmaceuticals in the world are looking for ways to come up with a drug that gives you nitric oxide. The problem is nitric oxide has a half-life of five seconds in the cell, it reacts with oxygen, reacts with water, reacts with nitrogen. So it's just there like a flash.

Ross: So nitric oxide that's in a lot of the supplement that the bodybuilders take like pre-workout right?

Dr. Perricone: Right because it gives you a pump and can help with muscle, but you know you're getting nitric oxide precursors because you can’t use nitric oxide itself. So things like beat very high nitrates which will convert to nitric oxide. So pharmaceutical companies are looking at nitric oxide donors for nitric oxide precursors, but I had this transdermal matrix I was working on for 20 years, and it carries very large molecules through the skin of biologically active matrix. So I said it is interesting what if I put nitric oxide into this matrix and exclude oxygen water, will it stabilize it from half-life of five seconds to something that would be usable? And since it is in a transdermal matrix will carry it through the skin. So when I actually did experiments, and we actually can get a lot of nitric oxide-like thousands on one part per million in the matrix the next question was, is it physiologically active?

Ross: So this isn’t just the precursors right?

Dr. Perricone: This is a real thing


Ross: Right which no one has done.

Dr. Perricone: No one has done it.

Ross: This is revolutionary?

Dr. Perricone: So I just had to gather a group of people, we worked on nitric oxide cream on the firms using the formula, and we had a huge amount of increase in blood flow. So not only was it was it in there, it was stable, and it was physiologically active.

Ross: So you are saying you put the cream on and you see the veins bulge?

Dr. Perricone: Oh you feel the increase in circulation. And so there a whole bunch of reasons why that is going to be important because pharmaceutical companies can now use the molecule of nitric oxide, not a precursor and not a donor. But the reason I’m telling you this whole story is I said if they can hold nitric oxide can I just make this hold hydrogen, so I make hydrogen creams? Sure enough, it can. So we had these hydrogen creams out there that have real hydrogen in it, it is stable because it’s in the matrix, you put on it and goes right through the skin and rub it in of course and it has really good clinical benefit. So once you get beauty from the inside out with the hydrogen water and on the outside in maintaining the skin. So it has all been exciting, and it is just a rush to get up in the morning and say what am I going to do today? I run around in circles and whatever it ends up pointing although in that direction.

Ross: Amazing so I think a lot of our listeners would really be curious about how does Dr. Perricone starts his day, what does he do, what skincare products do you use, what’s your morning routine? Like can you walk us through it?

Dr. Perricone: Oh sure I'd love to, and of course you would probably throw an arrow at me by the time I'm done, but I'm going to tell you anyway. So I wake up, the first thing I do is I have a little fridge in the bedroom and of course its loaded with hydrogen water.

Ross: Of course.

Dr. Perricone: And I pop it, and I take a half a teaspoon of powdered vitamin C it’s actually a swab of accessories it neutralizes vitamin C, and I drink it down with some hydrogen water. Then I take what I call my empty stomach vitamins that’s what some call amino acids some other things with hydrogen water, and then I go upstairs to my office and do my medication. The office has a nice table outside actually I have a little Japanese garden, and I do my meditation. And then I come in for round two, and I’ll take the rest of the supplements, I take lipoic acid and other things like vitamin E and just a whole mess of things like 120 long list. I do that, and then I will go upstairs to my gym, and I'll do a workout. So if it's a cardio day, I'll go out, and I'll basically walk if it is springs, if it is a weekday I’ll do about 45 minutes to an hour on weight resistance training, do a lot of things like abs and stretching. And then I work out a routine where I do my weight put between each weight; I'll do a Yoga to maintain just flexibility and then I have a little packet of vitamin I take with me. I'll grab a couple of cans of hydrogen water, and I head to the office or head for the airplane or head to New York City to do my interviews or whatever am doing. And so that’s what I do every day, and it’s made a difference, it continues to make a difference. I feel good, and I've been very fortunate.

Ross: I want to tell you this, you look amazing. Are you able to reveal how old you are?

Dr. Perricone: As a matter of fact back in June I had my 69 birthdays, and as I said I’m very fortunate, I feel good. One of the thing about meditation the way you start meditation is you really have to give thanks, and that just opens you up.

Ross: Gratitude

Dr. Perricone: And thank you thank you for the health I have today, and this beautiful place in the world you know and the whole thing and the hydrogen water put you into deep, deep state meditation.

Ross: Now what’s your skin care routine like?

Dr. Perricone: Okay, so skincare. So what I do is after I cleanse my face in the morning.

Ross: You use the Paragon cleanser?

Dr. Perricone: Of course yeah you don't want any rotation in your skin because this causes inflammation. So two days a week I use the White-Pollock acid-based core product they made many years ago called high potency face firming activator. And then in the evening, I'll use vitamin C 15 and two days a week.

Ross: I have been using that by the way. It magnifies, it takes away all the shine, it's amazing.

Dr. Perricone: Isn’t it amazing?

Ross: Also the vitamin C serum that you have is unbelievable.

Dr. Perricone: So you know when you value yourself with the squabble pod if that's what’s in there.

Ross: That’s in the serum or is that's in the Ester 15?

Dr. Perricone: That’s the Ester 15.

Ross: Okay

Dr. Perricone: What happens there it helps push is called the last production. So the matrix of your skin underneath is toxin elastin, and you need to have that firm for a useful and healthy skin. Then two days a week my days I use to do my experimental stuff cause am always working on something. So right now there's experimental that am using it has a lot of different things some of the older things like an egg membrane and it's got DMAE and some other active plus. It has got a little bit of the matrix just a little just to penetrate the skin not to go deep and then some new actives I am trying. So that's all I’m doing. And then on the weekends, I try to do a combination of things I'd like to get so if I get vitamin C along with the potency face firming activator, I use the hydrogen creams. And so it is constantly choosing because what you want to do is have a buffet to choose from.

Ross: You want to rotate it you don't want to use the same thing every day.

Dr. Perricone: Because you don’t want it to start losing effectiveness. Well, the nice thing about what we’re using they are all molecules that are natural for the body right. So if you're taking your medication, there’s something call taco floxs that means your body sees it as a foreign substance, it’s active and then we are going to down regulative till it becomes inactive. That does not happen to the regimen because those are natural molecules you never equate taco floxs to food. Food always works, it gives you energy same thing with the products. So I really take the natural approach, and so the skin routine is like a rotating thing. And listen to this infrared is amazing for giving your body energy, repairing and so I have an infrared sauna.

Ross: Great

Dr. Perricone: I use it about three times a week, and it really energizes. So if we have hydro water and infrared sauna I mean really you'll have to tie me down, I think that I’ll float away with energy and then is a whole other subject that we can spend hours talking about.

Ross: That is quite routine the other thing I wanted to make sure we recovered isa 160 patterns. You know I was looking through there and talking to you about some of the stuff but what blew me away is that some of these patterns have nothing to do with dermatology. You have a pattern there in aerospace things that are potentially being used by the military, can you talk a little bit about that?

Dr. Perricone: Yeah I always have interested in physics, and I learned to fly an airplane, so I love anything that had to do with aviation. And then I started thinking practically about what's needed, and somehow these ideas came. But when I was in the Army it was interesting that we were losing a lot of our fighter pilots because they would be in the air over Vietnam and you have a lot of warnings in the cockpit, you’ll get flashing lights, and you'll get audio warnings. And they were so overwhelmed with information even though a surface air of missile was coming at them, they sat right through and got blown out of the air. So I thought about that and said hmm how would I do this f I wanted to get their attention. So I invented a flight suit and a flight helmet that actually has little tactile, but it's just like the vibrator of your phone, and they're all over the suit, and they are inside their helmet. And so if there's an incoming missile you have something called a vector radar that you plug into, and there's a little computer chip and will now vibrate exactly on the part of your body where that missile is aimed. It wakes you up right away and if you have to do it once maneuver. So that was one of my first patterns for aerospace.

Ross: Wow that is amazing you are quite the Renaissance man. This is unbelievable, and you were telling me that you develop this Delta spray that helps you sleep better can you talk a little bit about that?

Dr. Perricone: Yeah I also have a pharmaceutical company that is just experimental, it’s not the cell things, and all I had to do is the transdermal matrix where you put screen on your scanner, and it rapidly penetrates the skin. And that's important because there molecules that are biologically active mostly peptides that are incredible. They are tiny little peptides, but you can't them early or digest them, intravenously they are broken down by enzymes so if you are in the matrix you are protected. I perfected this matrix, and you can take these peptides and put it on your skin and if you do that they actually get in and they are biologically active. So there's a list of those, what those are what we call Delta sleep. And delta sleep is chemical because they have a little spray bottle and it has got the peptides and matrix, and you sprayed it on your tongue. And for the military when you're on active duty, and you're on a mission especially in combat you get to sleep in four-hour blocks of time, so it's difficult to get to sleep your adrenaline is pumping, and you have got to get up. So I thought what can we do to get these people to sleep like if they had to be alert anytime they would be alert. And so I found a series of peptides I call Delta sleep spray and you spray it on your tongue, and you just relax, and you go to sleep, but I can wake you up 15 minutes later or an hour later and you are wide awake and also these peptides to also help the body repair.

Ross: And so with these peptides like if you're in deep REM sleep like for 15 minutes, you could just wake someone up and...

Dr. Perricone: Right so it's not a narcotic, it's not hypnotic, so you're not going to be drowsy. You are just going to wake up you know, so you shake it off and you get back, and then a lot of other peptides I’m using are transdermal, and one is called TRH it's [inaudible] peptide there's nothing by the way. It can actually repair tissue, a lot of work on by Dr. Peter Begley out of Italy but he is trying to administer it with lozenges on the tongue, it doesn't work that way. So the transdermal carries large amounts of TRH to the body. What can it do? It does things like repair the skin; it can regenerate your pancreas, regenerate your kidneys, can help you with bone density and also have some possible effects as an anti-inflammatory.

Ross: That's amazing is the TRH currently used even in small micro doses in any other product you've done? Not yet?

Dr. Perricone: No not yet and so TRH in the transdermal, of course, they are reactive, and there is another one I use it is called GnRH release some hormone peptide. And that actually regenerates brain, cardiac muscle, bone density, and a tremendous effect on other organ systems. So between the two...

Ross: And that's transdermal as well?

Dr. Perricone: Yes,  transdermal

Ross: Can you mix the two?

Dr. Perricone: You sure can. So over a period of years just looking at this changes in people you may now even get bone density up from you know below normal you know really back to like age 30.

Ross: Really? So just by putting it on the skin?

Dr. Perricone: It absorbs and then it goes to work

Ross: And it increases bone density?

Dr. Perricone: Yeah it does. So it’s fascinating that why I had the pharmaceuticals experimental company and then other inventions right now having to do with aerospace. There's electronic countermeasures so if you're in an airplane let's say you're Air Force One and then it’s said that it always resistible by the way you send fliers out to try detour other ways or you could send a little countermeasures, the incoming will see you, and that’s a real plane or as little ball, or it could send out radio signals [inaudible] others to turn off the infrared signature on a plane which we really can't talk about details here because it is under secrecy for national security. And so all these things are still and then my nicest mode I think my most proclamation right now is these laser protective glasses. They look just like aviators glasses, but they screen out the red, blue and green laser. Now you probably found on the news that commercial pilots are constantly getting hit by people shooting lasers at them and I have no idea why they do this. It's the strangest thing 10,000 salsa a year. And I want to get something on the pilots that would block off the laser, but they need to color vision for their instruments and for navigation. We did a lot of work, worked with some of the best optical physicists in the world, and we got it through aviators. It looks like aviators, they feel like aviators.

Ross: Every pilot in the world should be using this?

Dr. Perricone: They should be using it, with laser your protected. So it's some of those stuff in the aerospace

Ross: And have the plane companies started to come to buy these glasses?

Dr. Perricone: Well interesting enough no and we talked to the pilots and the pilot's unions, and there are informing each other you are going to pay we're not going to pay. So that's where they are now I think they should really get moving before this...

Ross: Absolutely this is unbelievable you are like the Tesla of our age.

Dr. Perricone: Tesla has been my idol I've been studying Tesla since when I was just a little kid, I always loved science and got into it; my dad love science too, so he sent me in that direction. But if you can recall Tesla was right here at the turn of century with science that we still can't understand and still probably 100 years ahead of us.

Ross: I heard something was Tesla involving in anything with water anything similar parallels to the hydro water? I recall hearing something like.

Dr. Perricone: Yeah I’m trying to think about it because I was mostly interested in his electromagnetics which is phenomenal and which are probably being used now but probably in prime projects that’s not available to us yet but appear genius. So he could do calculus in his head without pieces of pens and paper, and he would build his inventions in his head because you can visualize things so incredibly crisp. Sometimes he could distinguish what reality was, what he was imagining. So he built the thing and it like electric motor he built in his head and then he'd write it and be running it in the background in his brain for a couple of weeks. Then he would go back to see where it is wearing out then make adjustments then build the thing that was perfect.

Ross: Wow that's another level

Dr. Perricone: Yeah that's another level that's so far above mankind, but he was a was really a good guy, a philanthropist and what he wanted to do was just improve the human condition. But he was blocked by all the big interest things he was coming up with; free energy was blocked by a big oil company with interest. He was blocked by the big investors; they isolated him. He had ways of transmitting energy wirelessly around the world, all he needed was the right antenna to download energy. We could have saved places in Africa and India, all blocked. He died alone in the NewYorker hotel know, and the governments swooped him within six hours.

Ross: They confiscated all his works, all his papers, everything.

Dr. Perricone: It’s all gone.

Ross: Imagine those inventions that could be in those papers right?

Dr. Perricone: Yeah I keep on dreaming if there was a way to time travel if I could just go back New York around 1895 and 1896 and go to his office and apply for a job.

Ross: Wow unbelievable and so your main focus right now it seems like you are shifting a lot of your focus to the hydrogen water. So obviously you really feel that this is going to be huge?

Dr. Perricone: In the 30 years of my work in the area of anti-aging, nutrition, and health I found nothing more effective, affordable, available, and non-toxic. And I think the effects are so important that if we have the population drink this maybe it will lower the health care costs by 25% or 40% which will mean close to trillion dollars a year here in the US alone and then you think about the third world countries. And this is easy to make, and now I am investing millions of dollars in this project. I am working hard, and the important thing is that it has to be stable and hundreds of tiny molecules go right through plastic right through glass, it even attacks aluminum. So the special powers we developed, so that will hold it and it entered in the cans we have a two-year shelf life, and it has to have therapeutic levels. So as long as you are above 1.0 parts per million, you are in the therapeutic range, we have had that of course. With your other products on the market when we tested with them that we're one-fourth of what they should be. So my fear is that people buy the wrong hydrogen water saying I don’t feel anything and they drop it, and so I think there should be some standards set.

Ross: Sure and this is so new right they don't have any regulation?

Dr. Perricone: No regulations but you know I am a bit of a fanatic about perfection, and if I am going to do this I am going to do this right. So we have done it, we have the technology, we are going to start selling it now, and fortunately, we're working with a brilliant guy like you in pure green. And the beauty of pure green is that you're doing the same thing remember your up-regulating NRF 2 with those fighter nutrients and now that you're selling hydro water alongside it, so it's like a double money. So we need visionaries like you to help us get the hydrogen water out to the world, but I do think that it's going to happen very rapidly and so important. And very body I give it to who have a certain need or a deficit finds a benefit I've never heard of.

Ross: So the next question. So sometimes the consumer see the hydrogen water on the shelves you know they don't really know the science behind it and they are like wait is hydrogen added to the water? They are like wait H2O doesn't that change the molecular structure? Can you just kind of dorm it down for the consumers. How do you explain like what’s going on here?

Dr. Perricone: So water is made of two hydrogens and oxygen but they are bound by a covalent bond, and that means they are no longer what they were. I mean they are now water, they are not hydrogen and oxygen. We're taking pure hydrogen which is H2 and dissolved it in the water just like you dissolve sugar in a cup of tea and it is just that extra hydrogen that's free and still has all the attributes of hydrogen, not water. But they're dissolved in water at a therapeutic level the and when you drink it that hydrogen is rapidly released from the water into your cells. And I say rapidly remember it started up-regulating NADH in two minutes in the skin, so it goes from the stomach to the skin. It still baffles my mind how quickly it does that, crosses the blood-brain barrier. So it benefits you see so many benefits and then of course at the end of the day when I talk to people about it, and they are like I drink hydrogen water, and it makes my skin radiant. I say well that’s great; I anticipated that. But that's nice; I love the people who have radiant skin. I am in the skincare business, but when I really think about the internal benefits, the study shows that it can be protective of the heart and perhaps they will heart disease it can reverse metabolic center which leads to type II diabetes and other problems with the cardiovascular system. It seems really protective of the brain, it turns off inflammation, and in some of the earlier experiments, it looks like it prevents against micro-trauma to the brain. So my big interest right now is to get these to the sports people, we know that people in NFL and we also know that even children playing football in junior high school are getting microtrauma. So we want them drinking hydrogen water as a way to hydrate because it can be protective of the brain. We don't have a long history here, but I'm pretty confident in the studies I've seen that it really protect the brain from that pathology. Because there is kind of a medical, epidemiological look at brain trauma and they've taken autopsies on 200 athletes that had issues, and they found particular lesions that are very identifiable. And these people have all different problems from Parkinson's disease to behavior disorders where they were like getting violent, and it is from constant microtrauma. So I'm betting that hydrogen water is going to help that, right now we are trying to work...

Ross: Was that doctor Daniel Haman? I know he did a study where you took old professional NFL players, and he did brain scans of the brain, and they showed that these guys literally had like chunks missing from their brain.

Dr. Perricone: Oh yeah! There’s a lot about that nowadays, and there are tower proteins that build up. But I am also going to be working on this. There is a really big company that is interested in a device where they could read in real time by imparting some energies into the brain, how is functioning. And so I want to see what happens, I want to contact them and see what happens. An abnormal brain drinks hydrogen water and then look at the changes in energy and that going to be critical study, we're going to do that soon.

Ross: Wow! I mean in Dr. Helmond research he found that he was actually able to restore different parts of the brain through supplementation and I'm sure I don't think he tested hydrogen. So I'm sure there could definitely be something there that with a hydrogen water and having higher concentrations of the hydrogen I wonder if that does have an effect on the brain.

Dr. Perricone: Yeah I’m certainly optimistic about that because it is just the cognitive changes you have. When you drink hydrogen water it means that certainly, something is taking place and then the animal study showing it does protect from inflammatory conditions. and so yes I think as time rolls out and we have more people on, and we have a longer history, we look at epidemiology and the changes. I think we can have so many applications for this it’s going to be phenomenal and it’s going to be so good for us.

Ross: This has been amazing thank you so much for your time here this was unbelievable, and we look forward to having you back on the show.

Dr. Perricone: Oh listen, thank you so much for the invitation and then thank you for your interest in hydrogen water and do I think we can change the world together.

Ross: Absolutely